Neohori is a village that is spread on the slope with many "mahalades" (neighborhoods) and a spectacular view of the lake. It's distance from Karditsa is 37 km and it belongs to the Municipal Section of Nevropolis Agrafa. It is also located at an altitude of 900-1050 m.
The name of Neohori and the existence of the place names "Paliohori" and "Ktiria" conclude to the hypothesis that there was an elder village which for a reason was dissolved and in its place was the New Village (Neohori).

With the Treaty of Tamasi in 1525, Neohori was designated as the capital of Agrafa and in 1526 it appears as the capital village.

It was the basement of the Fanari and Neochori Bishopric from the 14th century until the revolution of 1821. During the greek revolution of 1821, one of the major schools of Agrafa flourished in Neochori. In the Ottoman period there was a den of Klephts and the Armatoloi.

Neochori during the 16th and the 17th century reached its prosperity. There are testimonies of the two wealthy families of the region the one of Panagiotis Kouskoulas and of Panagiotis Morfesis. They funded the painting of many churches in the wider area of Agrafa and other utility projects.